INVENTORY ACCURACY OF MAINTENANCE ASSISTANCE MODULES (MAMS) ON SHIPS UTILIZING THE ORGANIZATIONAL MAINTENANCE MANAGEMENT SYSTEM – NEXT GENERATION (OMMS-NG)

Proper inventory management is crucial to the success of a naval warship’s completion of mission tasking and maintenance operational readiness. All U.S. naval warships require a predetermined inventory of Maintenance Assistance Modules (MAMs) to test and identify broken parts within a weapons or engineering system when failures occur. Once a part is identified as broken, shipboard personnel order that part through the Navy Supply system and return the MAMs to their appropriate inventory location. These are high-value assets that require 100% inventory validity. Fleet Logistics Center San Diego has raised concerns due to declining inventory accuracy results of MAM inventories. This study contains an analysis of the differences in inventory management procedures between a variety of naval assets, ascertains the most efficient practice of inventory management, and presents possible explanations for the loss of these high-value assets. The authors have determined that there is a disparity between a ship’s inventory validities and Type Commander’s (TYCOM’s) inventory validities due to an inadequate inventory management system and insufficient guidance in procedures and policies for managing MAMs.Lieutenant Commander, United States NavyLieutenant Commander, United States NavyLieutenant Commander, United States NavyApproved for public release. Distribution is unlimited

The gut virome:the ‘missing link’ between gut bacteria and host immunity?

The human gut virome includes a diverse collection of viruses that infect our own cells as well as other commensal organisms, directly impacting on our well-being. Despite its predominance, the virome remains one of the least understood components of the gut microbiota, with appropriate analysis toolkits still in development. Based on its interconnectivity with all living cells, it is clear that the virome cannot be studied in isolation. Here we review the current understanding of the human gut virome, specifically in relation to other constituents of the microbiome, its evolution and life-long association with its host, and our current understanding in the context of inflammatory bowel disease and associated therapies. We propose that the gut virome and the gut bacterial microbiome share similar trajectories and interact in both health and disease and that future microbiota studies should in parallel characterize the gut virome to uncover its role in health and disease

Leveraging Entrepreneurial Ambition and Innovation : A Global Perspective on Entrepreneurship, Competitiveness and Development

The study described in this report combines two unique datasets, the World Economic Forum’s Global Competitiveness Index data, which ranks the economic competitiveness of 144 economies, and Global Entrepreneurship Monitor’s assessment of entrepreneurial activity across 70 economies. Using five years of data from both sets, the study analyses a sample of 44 economies by first examining three aspects of entrepreneurial activity, then grouping economies into five types of entrepreneurial clusters, and finally developing a deeper understanding of each type of cluster. Lastly, the study delves into what policymaking best benefits the unique characteristics of different economies

The application of omics techniques to understand the role of the gut microbiota in inflammatory bowel disease

The aetiopathogenesis of inflammatory bowel diseases (IBD) involves the complex interaction between a patient’s genetic predisposition, environment, gut microbiota and immune system. Currently, however, it is not known if the distinctive perturbations of the gut microbiota that appear to accompany both Crohn’s disease and ulcerative colitis are the cause of, or the result of, the intestinal inflammation that characterizes IBD. With the utilization of novel systems biology technologies, we can now begin to understand not only details about compositional changes in the gut microbiota in IBD, but increasingly also the alterations in microbiota function that accompany these. Technologies such as metagenomics, metataxomics, metatranscriptomics, metaproteomics and metabonomics are therefore allowing us a deeper understanding of the role of the microbiota in IBD. Furthermore, the integration of these systems biology technologies through advancing computational and statistical techniques are beginning to understand the microbiome interactions that both contribute to health and diseased states in IBD. This review aims to explore how such systems biology technologies are advancing our understanding of the gut microbiota, and their potential role in delineating the aetiology, development and clinical care of IBD

Order within disorder: the atomic structure of ion-beam sputtered amorphous tantala (a-Ta2O5)

Amorphous tantala (a-Ta2O5) is a technologically important material often used in high-performance coatings. Understanding this material at the atomic level provides a way to further improve performance. This work details extended X-ray absorption fine structure measurements of a-Ta2O5 coatings, where high-quality experimental data and theoretical fits have allowed a detailed interpretation of the nearest-neighbor distributions. It was found that the tantalum atom is surrounded by four shells of atoms in sequence; oxygen, tantalum, oxygen, and tantalum. A discussion is also included on how these models can be interpreted within the context of published crystalline Ta 2O5 and other a-T2O5 studies

Serum microRNA profiling to distinguish papillary thyroid cancer from benign thyroid masses

Objectives: Papillary thyroid cancer (PTC) is increasing in incidence. Fine needle aspiration is the gold standard for diagnosis, but results can be indeterminate. Identifying tissue and serum biomarkers, like microRNA, is therefore desirable. We sought to identify miRNA that is differentially expressed in the serum of patients with PTC. Methods: Serum miRNA was quantified in 31 female thyroidectomy patients: 13 with benign disease and 18 with PTC. qPCR results were compared for significant fold-changes in 175 miRNAs, against a pooled control. Results: 128 miRNA qualified for analysis. There were identifiable fold-changes in miRNA levels between benign and control, and between PTC and control. There were statistically significant fold changes in the level of four miRNAs between benign and PTC: hsa-miR-146a-5p and hsa-miR-199b-3p were down-regulated, while hsa-let7b-5p and hsa-miR-10a-5p were up-regulated. Conclusions: MicroRNA is differentially expressed in the serum of patients with PTC. Serum miRNA has the potential to aid in thyroid cancer diagnosis

Spectropolarimetric Evidence for Radiatively Inefficient Accretion in an Optically Dull Active Galaxy

We present Subaru/FOCAS spectropolarimetry of two active galaxies in the Cosmic Evolution Survey. These objects were selected to be optically dull, with the bright X-ray emission of an AGN but missing optical emission lines in our previous spectroscopy. Our new observations show that one target has very weak emission lines consistent with an optically dull AGN, while the other object has strong emission lines typical of a host-diluted Type 2 Seyfert galaxy. In neither source do we observe polarized emission lines, with 3-sigma upper limits of P_BLR < 2%. This means that the missing broad emission lines (and weaker narrow emission lines) are not due to simple anisotropic obscuration, e.g., by the canonical AGN torus. The weak-lined optically dull AGN exhibits a blue polarized continuum with P = 0.78 +/- 0.07% at 4400 A < lambda_rest < 7200 A (P = 1.37 +/- 0.16% at 4400 A < lambda_rest < 5050 A). The wavelength dependence of this polarized flux is similar to that of an unobscured AGN continuum and represents the intrinsic AGN emission, either as synchrotron emission or the outer part of an accretion disk reflected by a clumpy dust scatterer. Because this intrinsic AGN emission lacks emission lines, this source is likely to have a radiatively inefficient accretion flow.Comment: Accepted to ApJ. 6 pages, 2 figure